GPCR Second Messengers

G-protein couple receptors are an important highly druggable gene family. Upon receptor activation, a wide range of second messengers are activated to illicit many different cellular responses. These second messengers include the mobilization of Ca2+, increase or reduction of intracellular cAMP, production of diacylglycerol and phospatidylinositols. These second messengers can be monitored kinetically using fluorescent reagents and biosensors.


GPCR Signaling Pathways
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Calcium Kinetics
Calcium Kinetics



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